In humans, the liver is generally considered to be the major organ contributing to drug
metabolism, but studies during the last years have suggested an important role of the extra …

OBJECTIVES: Glutathione (GSH) and enzymes cooperating with it–glutathione peroxidase
(GSHPx), glutathione S-transferase (GST) and glutathione reductase (GSHR)–play crucial …

The polymorphic human GSTP1 gene locus encodes proteins that differentially metabolize
electrophilic substrates, including, many chemotherapeutic agents used in clinical cancer …

F-box only protein 8 (FBX8), as a critical component of the SKP1-CUL1-F-box (SCF) E3
ubiquitin ligases, has been associated with several malignancies through interacting with a …

In recent years much attention has been focused on the role of glutathione (GSH) and GSH-
related enzymes such as glutathione peroxidase (GSH Px), glutathione reductase (GSH …

Background Chemoprevention by dietary constituents has emerged as a novel approach to
control stomach cancer incidence. We therefore evaluated the chemopreventive effects of …

Detoxification mechanisms can play a pivotal role in determining tumor cell responses to
platinum-based chemotherapy. Glutathione S-transferase-pi (GSTP1) belongs to a …

OBJECTIVES: To develop an indirect enzyme-linked immunosorbent assay (ELISA) for
measuring class-π glutathione S-transferase (GST) in plasma, and tissue biopsies obtained …

Background and Objectives: Despite improvements in screening programs, a large number
of patients with colorectal cancer (CRC) are diagnosed in an advanced disease stage …

Background: Glutathione S-transferase (GST) enzymes are involved in electrophile
detoxification. The authors investigated the association between GST genotype and survival …