ABSTRACT C-terminal Binding Proteins (CtBP) 1 and 2 are oncogenic transcriptional co-
regulators overexpressed in many cancer types, with their expression level correlating to …

C-terminal binding proteins (CtBPs) were initially identified as binding partners for the E1A-
transforming proteins. Although the invertebrate genome encodes one CtBP protein, two …

Background: Changes in metabolism have been suggested to contribute to the aberrant
phenotype of vascular wall cells, including fibroblasts, in pulmonary hypertension (PH) …

The C-terminal binding protein (CtBP) is a NADH-dependent transcriptional repressor that
links carbohydrate metabolism to epigenetic regulation by recruiting diverse histone …

Gene transcription is strictly controlled by transcriptional complexes, which are assemblies
of transcription factors, transcriptional regulators, and co-regulators. Mammalian genomes …

Identification of direct modulators of transcription factor protein–protein interactions is a key
challenge for ligand discovery that promises to significantly advance current approaches to …

The recruitment and subsequent polarization of inflammatory monocytes/macrophages in
the perivascular regions of pulmonary arteries is a key feature of pulmonary hypertension …

Glycolysis and hypoxia are key regulators of human embryonic stem cell (hESC) self-
renewal, but how changes in metabolism affect gene expression is poorly understood. C …

Transcriptional corepressor proteins have emerged as an important facet of cancer etiology.
These corepressor proteins are often altered by loss-or gain-of-function mutations, leading …

The HIPK2 (serine/threonine homeodomain-interacting protein kinase 2) is a “caretaker”
gene, its inactivation increases tumorigenicity while its activation inhibits tumor growth. This …