Sarcopenia and frailty in decompensated cirrhosis

P Tandon, AJ Montano-Loza, JC Lai, S Dasarathy… - Journal of …, 2021 - Elsevier
In patients with decompensated cirrhosis, sarcopenia and frailty are prevalent. Although
several definitions exist for these terms, in the field of hepatology, sarcopenia has commonly …

The association between sarcopenia and diabetes: from pathophysiology mechanism to therapeutic strategy

H Chen, X Huang, M Dong, S Wen… - … Syndrome and Obesity, 2023 - Taylor & Francis
Diabetes and sarcopenia are emerging as serious public health issues. Sarcopenia, an age-
related disorder characterized by loss of skeletal muscle mass and function, is recognized …

Riding the tiger–physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

MD Brand - Critical reviews in biochemistry and molecular biology, 2020 - Taylor & Francis
Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation

W Hao, R Cha, M Wang, J Li, H Guo, R Du, F Zhou… - ACS …, 2023 - ACS Publications
Intestinal metabolism-related diseases, such as constipation, inflammatory bowel disease,
irritable bowel syndrome, and colorectal cancer, could be associated with the dysfunction of …

Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes

Y Zhu, Y Zhang, Y Li, C Guo, Z Fan, Y Li, M Yang… - Journal of Hazardous …, 2022 - Elsevier
Silica nanoparticles (SiNPs) are derived from manufactured materials and the natural
environment, and they cause detrimental effects on human health via various exposure …

Adaptive exhaustion during prolonged intermittent hypoxia causes dysregulated skeletal muscle protein homeostasis

AH Attaway, A Bellar, S Mishra… - The Journal of …, 2023 - Wiley Online Library
Nocturnal hypoxaemia, which is common in chronic obstructive pulmonary disease (COPD)
patients, is associated with skeletal muscle loss or sarcopenia, which contributes to adverse …

NAD supplement alleviates intestinal barrier injury induced by ethanol via protecting epithelial mitochondrial function

W Li, Y Zhou, N Pang, Q Hu, Q Li, Y Sun, Y Ding, Y Gu… - Nutrients, 2022 - mdpi.com
Background: The epithelial tight junction is an important intestinal barrier whose disruption
can lead to the release of harmful intestinal substances into the circulation and cause …

[HTML][HTML] Alcohol and skeletal muscle in health and disease

L Simon, BL Bourgeois, PE Molina - Alcohol Research: Current …, 2023 - ncbi.nlm.nih.gov
PURPOSE Alcohol-related myopathy is one of the earliest alcohol-associated pathological
tissue changes that is progressively exacerbated by cumulative long-term alcohol misuse …

[HTML][HTML] Multiomics-identified intervention to restore ethanol-induced dysregulated proteostasis and secondary sarcopenia in alcoholic liver disease

SS Singh, A Kumar, N Welch, J Sekar… - Cellular physiology …, 2021 - ncbi.nlm.nih.gov
Methods: Studies were performed in ethanol-treated differentiated C2C12 myotubes and
physiological relevance established in an ethanol-fed mouse model of alcohol-related liver …

Cancer cachexia in a mouse model of oxidative stress

JL Brown, MM Lawrence, B Ahn, P Kneis… - Journal of Cachexia …, 2020 - Wiley Online Library
Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up
to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and …