Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Acute myocardial infarction (AMI) is the leading cause of death worldwide. Its associated
mortality, morbidity and complications have significantly decreased with the development of …

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the
potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of …

Nitrite represents a circulating and tissue storage form of NO whose bioactivation is
mediated by the enzymatic action of xanthine oxidoreductase, nonenzymatic …

Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins,
calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the …

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the …

The widespread introduction of fibrinolytics and recently also PTCA in the treatment of
myocardial infarction has changed the picture of modern cardiology. But this therapy also …

Over the past decade, an enormous number of studies (> 100) have focused on the role of
nitric oxide (NO) in myocardial ischemia. It is important to distinguish the function of NO in …

Background—Endothelial nitric oxide (eNO) bioavailability is severely reduced after
myocardial infarction (MI) and in heart failure. Statins enhance eNO availability by both …

The role of reactive oxygen species and its effects on aging has received considerable
attention in the past 47 years since Dr. Denham Harman first proposed the “free radical …