The endocannabinoid system in guarding against fear, anxiety and stress

B Lutz, G Marsicano, R Maldonado… - Nature Reviews …, 2015 - nature.com
The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

CB1 receptor signaling in the brain: extracting specificity from ubiquity

A Busquets-Garcia, J Bains, G Marsicano - Neuropsychopharmacology, 2018 - nature.com
Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Glucose metabolism links astroglial mitochondria to cannabinoid effects

D Jimenez-Blasco, A Busquets-Garcia… - Nature, 2020 - nature.com
Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby
allowing neuronal activity and behavioural responses,,,–. By contrast, astrocytes are under …

Neurobiological mechanisms of nicotine reward and aversion

L Wills, JL Ables, KM Braunscheidel… - Pharmacological …, 2022 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …

Distinct projections from the infralimbic cortex exert opposing effects in modulating anxiety and fear

YH Chen, JL Wu, NY Hu, JP Zhuang… - The Journal of …, 2021 - Am Soc Clin Investig
Anxiety-related disorders can be treated by cognitive therapies and transcranial magnetic
stimulation, which involve the medial prefrontal cortex (mPFC). Subregions of the mPFC …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

Astroglial CB1 receptors determine synaptic D-serine availability to enable recognition memory

LM Robin, JFO da Cruz, VC Langlais… - Neuron, 2018 - cell.com
Bidirectional communication between neurons and astrocytes shapes synaptic plasticity and
behavior. D-serine is a necessary co-agonist of synaptic N-methyl-D-aspartate receptors …

A signalling pathway for transcriptional regulation of sleep amount in mice

R Zhou, G Wang, Q Li, F Meng, C Liu, R Gan, D Ju… - Nature, 2022 - nature.com
In mice and humans, sleep quantity is governed by genetic factors and exhibits age-
dependent variation,–. However, the core molecular pathways and effector mechanisms that …

Sex differences in fear extinction

ER Velasco, A Florido, MR Milad, R Andero - … & Biobehavioral Reviews, 2019 - Elsevier
Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …

Anatomical and single-cell transcriptional profiling of the murine habenular complex

ML Wallace, KW Huang, D Hochbaum, M Hyun… - Elife, 2020 - elifesciences.org
The lateral habenula (LHb) is an epithalamic brain structure critical for processing and
adapting to negative action outcomes. However, despite the importance of LHb to behavior …