Microglia are resident macrophages of the brain, performing roles related to brain
homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic …

Decline in ovarian reserve with advancing age is associated with reduced fertility and the
emergence of metabolic disturbances, osteoporosis, and neurodegeneration. Recent …

Abstract Analysis of retina cell type-specific epigenetic and transcriptomic signatures is
crucial to understanding the pathophysiology of retinal degenerations such as age-related …

Modern molecular and biochemical neuroscience studies require analysis of specific
cellular populations derived from brain tissue samples to disambiguate cell type-specific …

Cognitive behaviors, such as episodic memory formation, are complex processes involving
coordinated activity in multiple brain regions. However, much of the research on hormonal …

Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still
being determined after previously being thought to be absent from the brain. MHC-I …

Neuroinflammation and microglial iron load are significant hallmarks found in several
neurodegenerative diseases. In in vitro systems, microglia preferentially upregulate the iron …

Worldwide, an ever-increasing number of women are prescribed estrogen-modulating
therapies (EMTs) for the treatment of breast cancer. In parallel, aging of the global …

Epigenetic regulation of gene expression occurs in a cell type-specific manner. Current cell-
type specific neuroepigenetic studies rely on cell sorting methods that can alter cell …

Mice lacking the superoxide anion scavenger CuZn superoxide dismutase (Sod1−/− mice)
develop a number of age-related phenotypes, including an early progression of muscle …