Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
Genetic links between ovarian ageing, cancer risk and de novo mutation rates
Human genetic studies of common variants have provided substantial insight into the
biological mechanisms that govern ovarian ageing. Here we report analyses of rare protein …
biological mechanisms that govern ovarian ageing. Here we report analyses of rare protein …
A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies
Mitochondrial disorders have the highest incidence among congenital metabolic disorders
characterized by biochemical respiratory chain complex deficiencies. It occurs at a rate of 1 …
characterized by biochemical respiratory chain complex deficiencies. It occurs at a rate of 1 …
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups
T Hirabayashi, M Kawaguchi, S Harada, M Mouri… - Cell Reports, 2023 - cell.com
Choline supplies methyl groups for regeneration of methionine and the methyl donor S-
adenosylmethionine in the liver. Here, we report that the catabolism of membrane …
adenosylmethionine in the liver. Here, we report that the catabolism of membrane …
Phospholipases: an overview
Phospholipases are lipolytic enzymes that hydrolyze phospholipid substrates at specific
ester bonds. Phospholipases are widespread in nature and play very diverse roles from …
ester bonds. Phospholipases are widespread in nature and play very diverse roles from …
Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia
Patatin-like phospholipase domain-containing lipase 8 (PNPLA8), one of the calcium-
independent phospholipase A2 enzymes, is involved in various physiological processes …
independent phospholipase A2 enzymes, is involved in various physiological processes …
Biallelic mutations in TBCD, encoding the tubulin folding cofactor D, perturb microtubule dynamics and cause early-onset encephalopathy
E Flex, M Niceta, S Cecchetti, I Thiffault, MG Au… - The American Journal of …, 2016 - cell.com
Microtubules are dynamic cytoskeletal elements coordinating and supporting a variety of
neuronal processes, including cell division, migration, polarity, intracellular trafficking, and …
neuronal processes, including cell division, migration, polarity, intracellular trafficking, and …
Current Knowledge on Mammalian Phospholipase A1, Brief History, Structures, Biochemical and Pathophysiological Roles
S Yaginuma, H Kawana, J Aoki - Molecules, 2022 - mdpi.com
Phospholipase A1 (PLA1) is an enzyme that cleaves an ester bond at the sn-1 position of
glycerophospholipids, producing a free fatty acid and a lysophospholipid. PLA1 activities …
glycerophospholipids, producing a free fatty acid and a lysophospholipid. PLA1 activities …