[HTML][HTML] Death by TNF: a road to inflammation

G Van Loo, MJM Bertrand - Nature Reviews Immunology, 2023 - nature.com
Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics
that neutralize TNF are among the most successful drugs for the treatment of chronic …

[HTML][HTML] NF-κB: at the borders of autoimmunity and inflammation

L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

[HTML][HTML] Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

L Mifflin, D Ofengeim, J Yuan - Nature reviews Drug discovery, 2020 - nature.com
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

[HTML][HTML] Cell death

K Newton, A Strasser, N Kayagaki, VM Dixit - Cell, 2024 - cell.com
Cell death supports morphogenesis during development and homeostasis after birth by
removing damaged or obsolete cells. It also curtails the spread of pathogens by eliminating …

Breaking the chains: deubiquitylating enzyme specificity begets function

MJ Clague, S Urbé, D Komander - Nature reviews Molecular cell …, 2019 - nature.com
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

[HTML][HTML] Tumour necrosis factor signalling in health and disease

J Holbrook, S Lara-Reyna, H Jarosz-Griffiths… - …, 2019 - ncbi.nlm.nih.gov
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to
modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a …

Mechanisms of deubiquitinase specificity and regulation

TET Mevissen, D Komander - Annual review of biochemistry, 2017 - annualreviews.org
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

[HTML][HTML] The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues

JD Webster, D Vucic - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation

K Manthiram, Q Zhou, I Aksentijevich, DL Kastner - Nature immunology, 2017 - nature.com
Autoinflammatory diseases were first recognized nearly 20 years ago as distinct clinical and
immunological entities caused by dysregulation in the innate immune system. Since then …

[HTML][HTML] Disorders of ubiquitylation: unchained inflammation

DB Beck, A Werner, DL Kastner… - Nature Reviews …, 2022 - nature.com
Ubiquitylation is an essential post-translational modification that regulates intracellular
signalling networks by triggering proteasomal substrate degradation, changing the activity of …