Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Stroke is the second leading cause of death worldwide; however, the treatment choices
available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted …

Receptor interacting protein kinase 1 (RIPK1) mediates cell death and inflammatory
signaling and is increased in multiple sclerosis (MS) brain samples. Here, we investigate the …

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse
cellular processes including cell death/survival, inflammation, iron delivery and cell …

The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific
biochemical markers are not available. Here, we investigated the potential of cerebrospinal …

Hypoxic-ischemic brain damage (HIBD) is a common cause of death or mental retardation in
newborns. Ferroptosis is a novel form of iron-dependent cell death driven by lipid …

Leukocyte migration into the central nervous system (CNS) represents a central process in
the development of neurological diseases with a detrimental inflammatory component …

Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …

Amyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease
characterized by the loss of motor neurons. Dysregulated peripheral immunity has been …

Importance Biomarkers distinguishing nonrelapsing progressive disease biology from
relapsing biology in multiple sclerosis (MS) are lacking. Cerebrospinal fluid (CSF) is an …