Metabolomics for clinical biomarker discovery and therapeutic target identification

C Lin, Q Tian, S Guo, D Xie, Y Cai, Z Wang, H Chu… - Molecules, 2024 - mdpi.com
As links between genotype and phenotype, small-molecule metabolites are attractive
biomarkers for disease diagnosis, prognosis, classification, drug screening and treatment …

Metabolomics in cirrhosis: Recent advances and opportunities

Y Luo, C Zhang, X Nong, Y Gao, L Wang, G Ji, T Wu - Clinica Chimica Acta, 2024 - Elsevier
Liver cirrhosis (LC) represents a significant hepatic disorder that persistently commands the
attention of the scientific community, especially concerning its pathogenesis and therapeutic …

Predicting effect of anti-PD-1/PD-L1 inhibitors therapy for hepatocellular carcinoma by detecting plasma metabolite based on UHPLC-MS

B Liu, J Shi, R Su, R Zheng, F Xing, Y Zhang… - Frontiers in …, 2024 - frontiersin.org
Introduction Anti-PD-1/PD-L1 inhibitors therapy has become a promising treatment for
hepatocellular carcinoma (HCC), while the therapeutic efficacy varies significantly among …

Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin

M Meroni, M Longo, P Dongiovanni - Frontiers in Endocrinology, 2024 - frontiersin.org
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) constitutes the
commonest cause of chronic liver disorder worldwide, whereby affecting around one third of …

血液代谢标志物在原发性肝癌治疗反应及预后预测中的应用.

刘志英, 周智航, 何松 - Journal of Clinical Hepatology …, 2023 - search.ebscohost.com
原发性肝癌是全球严重的癌症负担之一. 代谢重编程是癌症的一种表型, 血液代谢标志物与代谢
重编程密切相关, 可以预测肝癌患者复发风险和生存期情况或评估肝癌治疗反应 …

Research advances in the role of blood metabolic markers in the treatment response and prognosis prediction of primary liver cancer

LIU Zhiying, Z Zhihang, HE Song - 临床肝胆病杂志, 2023 - lcgdbzz.org
Primary liver cancer is one of the most severe cancer burdens around the world. Metabolic
reprogramming is one phenotype of cancer, and blood metabolic markers are closely …