In vivo, the human genome functions as a complex, folded, three-dimensional chromatin
polymer. Understanding how the human genome is spatially organized and folded inside …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to
explore changes in epigenome structure and their functional implications during …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Background Genomes are organized in vivo in the form of chromosomes. Each chromosome
occupies a distinct nuclear subvolume in the form of a chromosome territory. The spatial …

Whether chromosomes maintain their nuclear positions during interphase and from one cell
cycle to the next has been controversially discussed. To address this question, we …

Background Similarities as well as differences in higher order chromatin arrangements of
human cell types were previously reported. For an evolutionary comparison, we now studied …

In spite of strong evidence that the nucleus is a highly organized organelle, a consensus on
basic principles of the global nuclear architecture has not so far been achieved. The …

Differential painting of all five chromosome pairs of Arabidopsis thaliana revealed for the first
time the interphase chromosome arrangement in a euploid plant. Side-by-side arrangement …

▪ Abstract Eukaryotic genomes are distributed on linear chromosomes that are grouped
together in the nucleus, an organelle separated from the cytoplasm by a characteristic …