Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …

Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

The etiopathogenesis of endometriosis is a multifactorial process resulting in a
heterogeneous disease. Considering that endometriosis etiology and pathogenesis are still …

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic
disorders in premenopausal women. Heterogeneous by nature, PCOS is defined by a …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

The global obesity epidemic has necessitated the search for better intervention strategies
including the exploitation of the health benefits of some gut microbiota and their metabolic …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …