An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite
retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent …

As one of the most common malignancies worldwide, gastric cancer contributes to cancer
death with a high mortality rate partly responsible for its out-of-control progression as well as …

Chronic environmental stress can profoundly impact cell and body function. Although the
underlying mechanisms are poorly understood, epigenetics has emerged as a key link …

Expression of promyelocytic leukemia zinc finger (PLZF) protein directs the effector
differentiation of invariant NKT (iNKT) cells and IL-4+ γδ NKT cells. In this study, we show …

Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia
(AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most …

Gallbladder cancer (GBC) is a malignant cancer with very poor prognosis. Although
promyelocytic leukemia zinc-finger protein (PLZF) was reported to be deregulated in …

Background Non-WNT/non-SHH medulloblastoma (MB) is one of the subtypes with the
highest genetic heterogeneity in MB, and its current treatment strategies have unsatisfactory …

Spermatogonial stem cell (SSC) self‐renewal is regulated by reciprocal interactions
between Sertoli cells and SSCs in the testis. In a previous study, microtubule‐associated …

Chromosome region maintenance 1 (CRM1) is a major nuclear export receptor protein and
contributes to cell homeostasis by mediating the transport of cargo from the nucleus to the …