Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

Bone marrow (BM)-mediated trained innate immunity (TII) is a state of heightened immune
responsiveness of hematopoietic stem and progenitor cells (HSPC) and their myeloid …

Abstract Purpose of Review The role of oral bacteremia and periodontal inflammation
driving atherosclerosis is still under investigation. This review article highlights the role of …

The principle of trained immunity represents innate immune memory due to sustained,
mainly epigenetic, changes triggered by endogenous or exogenous stimuli in bone marrow …

Periodontitis and caries are driven by complex interactions between the oral microbiome
and host factors, ie inflammation and dietary sugars, respectively. Animal models have been …

Periodontitis and diabetes are two major global health problems despite their prevalence
being significantly underreported and underestimated. Both epidemiological and …

Background While growing evidence suggests a link between periodontal disease (PD) and
cardiovascular disease (CVD), the independence of this association and the pathway …

Inflammation plays a crucial role in the onset and development of atherosclerosis.
Periodontitis is a common chronic disease linked to other chronic inflammatory diseases …

There is mounting evidence demonstrating that oral dysbiosis causes periodontal disease
and promotes the development of cardiovascular disease. The advancement of omics …