The inflammatory response involves the activation of several cell types to fight insults
caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …

Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …

Serine metabolism is reportedly involved in immune cell functions, but whether and how
serine metabolism regulates macrophage polarization remain largely unknown. Here, we …

Plasmacytoid dendritic cells (pDCs) chronically produce type I interferon (IFN-I) in
autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus …

Summary T helper type 2 (Th2) cytokine-activated M2 macrophages contribute to
inflammation resolution and wound healing. This study shows that IL-4-primed …

The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the
mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to …

Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in
macromolecule synthesis, neutralizing oxidative stress, and regulating methylation reactions …

Acclimation and adaptation of metabolism to a changing environment are key processes for
plant survival and reproductive success. In the present study, 241 natural accessions of …