DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and
are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer …

Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …

A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde
dehydrogenase 2 (ALDH2). The correlation between ALDH2 dysfunction and …

Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

Platinum-based drugs have maintained their preeminent position in cancer treatment
regimens even four decades after the approval of cisplatin. Although these agents have …

Transcriptional dysregulation is a hallmark of cancer and can be an essential driver of
cancer initiation and progression. Loss of transcriptional control can cause cancer cells to …

DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and
transcription. When cross-links are detected at stalled replication forks, ATR kinase …

DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway.
The FANCD2–FANCI (D2–I) protein complex is central to this process as it initiates repair by …

Long noncoding RNAs (lncRNAs) play diverse roles in biological processes, but their
expression profiles and functions in cervical carcinogenesis remain unknown. By RNA …

FANCI: FANCD2 monoubiquitination is a critical event for replication fork stabilization by the
Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication …