Simple Summary As life expectancy is increasing, the older population is rapidly growing.
However, older patients with cancer are still underrepresented in clinical trials, making …

Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

Nitroxides are stable free radicals that contain a nitroxyl group with an unpaired electron. In
this paper, we present the properties and application of nitroxides as antioxidants and …

DNA oxidation, which can have potentially serious mutagenic consequences, commonly
accompanies exposure to environmental mutagens. Oxidised bases can be measured …

The one-electron oxidation product of guanine, 8-oxo-7, 8-dihydroguanine (8-oxoG), is an
abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to …

The term “cell‐free DNA”(cfDNA) was recently coined for DNA fragments from
plasma/serum, while DNA present in in vitro cell culture media is known as extracellular …

This paper presents evidence that damage to nuclear DNA (nDNA) is a direct cause of aging
in addition to the effects of nDNA damage on cancer, apoptosis, and cellular senescence …

DNA damage and DNA repair may mediate several cellular processes, like replication and
transcription, mutagenesis and apoptosis and thus may be important factors in the …

Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at
which stage of the disease this phenomenon occurs. In the examined groups of patients with …

Aging is a complex process of organism decline in physiological functions. There is no clear
theory explaining this phenomenon, but the most accepted one is the oxidative stress theory …