Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Although the first construction of a functionalized bicyclo [3.2. 1] skeleton was proposed by
Kompa and Hirn in 1903 using an intramolecular Piria reaction, 1 the first comprehensive …

Abstract ortho‐Quinone methides (o‐QMs) are emerging as highly useful intermediates, the
inherent reactivity of which can be used in linchpin reactions for the construction of complex …

A synthetic strategy based on biogenetic building blocks for the collective and divergent
biomimetic synthesis of cleistoperlones A− F, a cinnamoylphloroglucinol collection …

Hyperforin is the compound responsible for the effectiveness of St. John's wort (Hypericum
perforatum) as an antidepressant, but its complete biosynthetic pathway remains unknown …

Xanthohumol (XN) and demethylxanthohumol (DMX) are specialized prenylated
chalconoids with multiple pharmaceutical applications that accumulate to high levels in the …

With their fascinating biological profiles and stunningly complex molecular architectures, the
polycyclic polyprenylated acylphloroglucinols (PPAPs) have long provided a fertile playing …

Bitter acids (α and β types) account for more than 30% of the fresh weight of hop (Humulus
lupulus) glandular trichomes and are well known for their contribution to the bitter taste of …

In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of
complex natural products is laid out, backed by abundant practical examples from the …

A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural
product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled …