Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have
essential physiological roles in mature organisms. Here we describe the first known small …

Juvenile hemochromatosis is an iron-overload disorder caused by mutations in the genes
encoding the major iron regulatory hormone hepcidin (HAMP) and hemojuvelin (HFE2). We …

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and have
diverse functions during development and organogenesis. BMPs play a major role in …

In thalassemia, deficient globin-chain production during erythropoiesis results in anemia,,.
Thalassemia may be further complicated by iron overload (frequently exacerbated by blood …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …