In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

In the past five years, skeletal muscle has emerged as a paradigm of “nitric oxide”(NO)
function and redox-related signaling in biology. All major nitric oxide synthase (NOS) …

Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse
and often opposing biological activities. The diversity in response to this simple diatomic …

The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-
dependent manner. An animal model for temporal lobe epilepsy, ie kainate-induced limbic …

Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such …

Alzheimer's disease is the fourth largest cause of death for people over 65 years of age.
Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being …

Mechanistic descriptions of cAMP production have evolved significantly since the 1960s
when Sutherland and Rall hypothesized the existence of a single polypeptide that would …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations
capable of causing brain circuitry dysfunctions in AD may take several years to develop …

Until recently cysteine residues, especially those located extracellularly, were thought to be
important for metal coordination, catalysis and protein structure by forming disulfide bonds …

Nitric oxide (NO), despite an apparently simple diatomic structure, has a wide variety of
functions in both physiology and pathology and within every major organ system. It has …