Importance Critical bleeding is associated with a high mortality rate in patients with trauma.
Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …

Trauma is a leading cause of death worldwide in persons under 44 years of age, and
uncontrolled haemorrhage is the most common preventable cause of death in this patient …

This narrative review explores the pathophysiology, geographic variation, and historical
developments underlying the selection of fixed ratio versus whole blood resuscitation for …

The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism
of cancer drug resistance. They are also important in protecting normal tissue cells from …

Background Fibrinogen is the first coagulation protein to reach critical levels during
traumatic haemorrhage. This laboratory study compares paired plasma samples pre-and …

Early Fibrinogen Replacement to Treat the Endotheliopathy of Trauma: Novel Resuscitation
Strategies in Severe Trauma - PMC Skip to main content Here's how you know Official …

Traumatic-induced coagulopathy (TIC) is often associated with significant bleeding,
transfusion requirements, inflammation, morbidity, and mortality. This review considers TIC …

Introduction Acute hemorrhage is a global healthcare issue, and remains the leading
preventable cause of death in trauma. Acute severe hemorrhage can be related to traumatic …

Trauma-induced bleeding is a leading cause of preventable mortality worldwide. 1–3
Severely injured bleeding trauma patients frequently present with trauma-induced …