Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

The WNT/β-catenin signaling pathway is a highly conserved and tightly controlled molecular
mechanism that regulates embryonic development, cellular proliferation and differentiation …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death
worldwide. HCC can be cured by radical therapies if early diagnosis is done while the tumor …

Most tumours appear to contain a sub-population (s) of self-renewing and expanding stem
cells known as cancer stem cells (CSCs). The CSC model proposes that CSCs are at the …

Wnt7a/Fzd7 signaling stimulates skeletal muscle growth and repair by inducing the
symmetric expansion of satellite stem cells through the planar cell polarity pathway and by …

In recent decades, there have been tremendous improvements in burn care that have
allowed patients to survive severe burn injuries that were once fatal. However, a major …

Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with
hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted …