Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

A central question in the post-genomic era is how genes interact to form biological
pathways. Measurements of gene dependency across hundreds of cell lines have been …

Mitochondrial homeostasis depends on mitophagy, the programmed degradation of
mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

Mutations in mitochondrial acylglycerol kinase (AGK) cause Sengers syndrome, which is
characterized by cataracts, hypertrophic cardiomyopathy, and skeletal myopathy. AGK …

Mitochondrial complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its
biogenesis requires the assembly and integration of distinct intermediate modules, mediated …

Acylglycerol kinase (AGK) is a mitochondrial lipid kinase that catalyzes the phosphorylation
of monoacylglycerol and diacylglycerol to lysophosphatidic acid and phosphatidic acid …

Mitochondria are fundamental structures that fulfil important and diverse functions within
cells, including cellular respiration and iron-sulfur cluster biogenesis. Mitochondrial function …

Mitochondrial biogenesis requires the import of> 1,000 mitochondrial preproteins from the
cytosol. Most studies on mitochondrial protein import are focused on the core import …