Background: Pulmonary arterial hypertension (PAH) is a type of pulmonary hypertension
(PH) characterized by obliterative pulmonary vascular remodeling, resulting in right-sided …

Lupus nephritis is a severe organ manifestation of systemic lupus erythematosus, and its
pathogenesis involves complex etiology and mechanisms. Despite significant knowledge …

Background Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called
fenestrations, participating in the bidirectional transport between the vascular system and …

Reliable tools for macrophage identification in mouse tissues are critical for studies
investigating inflammatory and reparative responses. Transgenic reporter mice and anti …

In this study, we investigated the impact of the uremic toxin indoxyl sulfate on macrophages
and tubular epithelial cells and its role in modulating the response to lipopolysaccharide …

Methods: In this study, we investigated MCPIP1 expression in the liver and peripheral blood
mononuclear cells (PBMCs) collected from a cohort of 36 control and NAFLD patients …

Sterile inflammation either resolves the initial insult or leads to tissue damage. Kidney
ischemia/reperfusion injury (IRI) is associated with neutrophilic infiltration, enhanced …

Sterile inflammation contributes to the development of many liver diseases including non-
alcoholic fatty liver disease. Tumor necrosis factor alpha (TNFα) is a key cytokine driving …

Monocyte chemotactic protein-1-induced protein-1 (MCPIP-1) is highly expressed in
activated immune cells and negatively regulates immune responses, while the mechanisms …

Abstract MCPIP1 (called also Regnase-1) is a negative regulator of inflammation. Knockout
of the Zc3h12a gene, encoding Mcpip1 in cells of myeloid origin (Mcpip1 MKO), has a …