The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited
RL Rosenfield, DA Ehrmann - Endocrine reviews, 2016 - academic.oup.com
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …
hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989–1995 …
Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data
Background Because only 25% of cases of premature ovarian insufficiency (POI) have a
known etiology, the aim of this review was to summarize the associations and mechanisms …
known etiology, the aim of this review was to summarize the associations and mechanisms …
Ovarian follicular theca cell recruitment, differentiation, and impact on fertility: 2017 update
JAS Richards, YA Ren, N Candelaria… - Endocrine …, 2018 - academic.oup.com
The major goal of this review is to summarize recent exciting findings that have been
published within the past 10 years that, to our knowledge, have not been presented in detail …
published within the past 10 years that, to our knowledge, have not been presented in detail …
The ageing ovary and uterus: new biological insights
BACKGROUND Advanced maternal age is associated with reduced fertility and adverse
pregnancy outcomes. This review details recent developments in our understanding of the …
pregnancy outcomes. This review details recent developments in our understanding of the …
Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research
M Harada - Reproductive medicine and biology, 2022 - Wiley Online Library
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder
among reproductive‐age women and has lifelong effects on health. Methods In this review, I …
among reproductive‐age women and has lifelong effects on health. Methods In this review, I …
Is foetal hyperexposure to androgens a cause of PCOS?
P Filippou, R Homburg - Human Reproduction Update, 2017 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting reproductive-aged women. The pathophysiology of this syndrome is still not …
affecting reproductive-aged women. The pathophysiology of this syndrome is still not …
How is the number of primordial follicles in the ovarian reserve established?
The number of primordial follicles in the ovarian reserve is an important determinant of the
length of the ovarian lifespan, and therefore the fertility of an individual. This reserve …
length of the ovarian lifespan, and therefore the fertility of an individual. This reserve …
Estrogen receptor signaling during vertebrate development
Estrogen receptors are expressed and their cognate ligands produced in all vertebrates,
indicative of important and conserved functions. Through evolution estrogen has been …
indicative of important and conserved functions. Through evolution estrogen has been …
The developmental origins of the mammalian ovarian reserve
KJ Grive, RN Freiman - Development, 2015 - journals.biologists.com
The adult mammalian ovary is devoid of definitive germline stem cells. As such, female
reproductive senescence largely results from the depletion of a finite ovarian follicle pool …
reproductive senescence largely results from the depletion of a finite ovarian follicle pool …
At the crossroads of fate—somatic cell lineage specification in the fetal gonad
E Rotgers, A Jørgensen, HHC Yao - Endocrine reviews, 2018 - academic.oup.com
The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …