Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies

K Facecchia, LA Fochesato, SD Ray… - Journal of …, 2011 - Wiley Online Library
Besides fluorine, oxygen is the most electronegative element with the highest reduction
potential in biological systems. Metabolic pathways in mammalian cells utilize oxygen as the …

Impact of pesticides on environmental and human health

MFF Bernardes, M Pazin, LC Pereira… - … studies-cells, drugs …, 2015 - books.google.com
Pesticides constitute any substance or mixture of substances intended for preventing,
destroying, repelling, or mitigating any pest. They can also serve as plant regulators …

Mesenchymal stem cell therapy for paraquat poisoning: a systematic review and meta-analysis of preclinical studies

F He, A Zhou, S Feng, Y Li, T Liu - PLoS One, 2018 - journals.plos.org
Background Paraquat (PQ) poisoning can cause multiple organ failure, in which the lung is
the primary target organ. There is currently no treatment for PQ poisoning. Mesenchymal …

Paraquat induces pulmonary fibrosis through Wnt/β-catenin signaling pathway and myofibroblast differentiation

Z Sun, Z Yang, M Wang, C Huang, Y Ren, W Zhang… - Toxicology Letters, 2020 - Elsevier
Paraquat (PQ) poisoning-induced pulmonary fibrosis always results in fatal harm to patients.
Our study aimed to investigate the functions of the Wnt/β-catenin pathway in PQ-induced …

The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats

Y Sun, J Zhang, Y Yan, M Chi, W Chen, P Sun… - Environmental toxicology …, 2011 - Elsevier
To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-
induced acute lung injury, rats were divided into control, PQ-treated and PQ+ PC-treated …

[HTML][HTML] Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat‑induced pulmonary fibrosis

Z Yang, Z Sun, H Liu, Y Ren… - Molecular …, 2015 - spandidos-publications.com
It is well established that paraquat (PQ) poisoning can cause severe lung injury during the
early stages of exposure, finally leading to irreversible pulmonary fibrosis. Connective tissue …

Deficiency of multidrug and toxin extrusion 1 enhances renal accumulation of paraquat and deteriorates kidney injury in mice

Q Li, X Peng, H Yang, H Wang, Y Shu - Molecular pharmaceutics, 2011 - ACS Publications
Multidrug and toxin extrusion 1 (MATE1/solute carrier 47A1) mediates cellular transport of a
variety of structurally diverse compounds. Paraquat (PQ), which has been characterized in …

Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats

Z Liu, M Zhao, Q Zheng, H Zhao, W Hou… - Acta Pharmacologica …, 2013 - nature.com
Aim: To investigate the effects of the PPAR-γ agonist rosiglitazone on acute lung injury
induced by the herbicide paraquat (PQ) and the underlying mechanisms of action. Methods …

Protective effect of melatonin against herbicides-induced hepatotoxicity in rats

LL Almeida, GSGN Pitombeira, ÁAC Teixeira… - Toxicology …, 2021 - academic.oup.com
Exposure to the herbicides Paraquat and Roundup® may cause cell lesions due to an
increase in oxidative stress levels in different biological systems, even in the liver. The aim of …

Metallothioneins attenuate paraquat-induced acute lung injury in mice through the mechanisms of anti-oxidation and anti-apoptosis

M Ren, YM Wang, J Zhao, J Zhao, ZM Zhao… - Food and chemical …, 2014 - Elsevier
Paraquat (PQ) is a widely used herbicide, and lung is the primary target of PQ poisoning.
Metallothionein (MT) is a potent antioxidant and free radical scavenger, and has been …