Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation

KC Koskinas, YS Chatzizisis, AP Antoniadis… - Journal of the American …, 2012 - jacc.org
Restenosis and thrombosis are potentially fatal complications of coronary stenting with a
recognized multifactorial etiology. The effect of documented risk factors, however, cannot …

Frequency–time analysis, low-rank reconstruction and denoising of turbulent flows using SPOD

A Nekkanti, OT Schmidt - Journal of Fluid Mechanics, 2021 - cambridge.org
Four different applications of spectral proper orthogonal decomposition (SPOD) are
demonstrated on large-eddy simulation data of a turbulent jet. These are: low-rank …

Drug-eluting stent restenosis: effect of drug type, release kinetics, hemodynamics and coating strategy

MI Papafaklis, YS Chatzizisis, KK Naka… - Pharmacology & …, 2012 - Elsevier
Restenosis following stent implantation diminishes the procedure's efficacy influencing long-
term clinical outcomes. Stent-based drug delivery emerged a decade ago as an effective …

Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis

J Wang, X Jin, Y Huang, X Ran, D Luo… - Regenerative …, 2018 - academic.oup.com
Cardiovascular stent restenosis remains a major challenge in interventional treatment of
cardiovascular occlusive disease. Although the changes in arterial mechanical environment …

Results of FDA's first interlaboratory computational study of a nozzle with a sudden contraction and conical diffuser

SFC Stewart, P Hariharan, EG Paterson… - Cardiovascular …, 2013 - Springer
Abstract The US Food and Drug Administration recently hosted an interlaboratory study to
assess the suitability and methodology of computational fluid dynamics (CFD) for …

Hemodynamics in coronary arteries with overlapping stents

F Rikhtegar, C Wyss, KS Stok, D Poulikakos… - Journal of …, 2014 - Elsevier
Coronary artery stenosis is commonly treated by stent placement via percutaneous
intervention, at times requiring multiple stents that may overlap. Stent overlap is associated …

Hemodynamic effects of myocardial bridging in patients with hypertrophic cardiomyopathy

M Sharzehee, Y Chang, J Song… - American Journal of …, 2019 - journals.physiology.org
Myocardial bridging (MB) is linked to angina and myocardial ischemia and may lead to
sudden cardiac death in patients with hypertrophic cardiomyopathy (HCM). However, it …

Smartphone-based particle image velocimetry for cardiovascular flows applications: A focus on coronary arteries

GCA Caridi, E Torta, V Mazzi, C Chiastra… - … in Bioengineering and …, 2022 - frontiersin.org
An experimental set-up is presented for the in vitro characterization of the fluid dynamics in
personalized phantoms of healthy and stenosed coronary arteries. The proposed set-up was …

Proper orthogonal decomposition truncation method for data denoising and order reduction

MC Brindise, PP Vlachos - Experiments in Fluids, 2017 - Springer
Proper orthogonal decomposition (POD) is used widely in experimental fluid dynamics for
reducing noise in a measured flow field. The efficacy of POD is governed by the selection of …

Reduced-order modeling of left ventricular flow subject to aortic valve regurgitation

G Di Labbio, L Kadem - Physics of Fluids, 2019 - pubs.aip.org
The present focus of heart flow studies is largely based on flow within the left ventricle and
how this flow changes when subject to disease. However, despite recent advancements, a …