The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery

G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

Carrier-free nanomedicines for cancer treatment

LH Liu, XZ Zhang - Progress in Materials Science, 2022 - Elsevier
The last decade witnessed the great advances in the development of nanomedicines. As a
kind of attractive nanomedicine, carrier-free nanomedicines received extensive …

[HTML][HTML] Recent advances in the application of vitamin E TPGS for drug delivery

C Yang, T Wu, Y Qi, Z Zhang - Theranostics, 2018 - ncbi.nlm.nih.gov
D-ɑ-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) has been
approved by FDA as a safe adjuvant and widely used in drug delivery systems. The …

Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy

Z Jin, Q Gao, K Wu, J Ouyang, W Guo… - Advanced Drug Delivery …, 2023 - Elsevier
The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

Recent advances in colon drug delivery systems

R Arévalo-Pérez, C Maderuelo, JM Lanao - Journal of Controlled Release, 2020 - Elsevier
As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Epigallocatechin gallate: Phytochemistry, bioavailability, utilization challenges, and strategies

S Mehmood, M Maqsood, N Mahtab… - Journal of Food …, 2022 - Wiley Online Library
Epigallocatechin gallate (EGCG), a green tea catechin, has gained the attention of current
study due to its excellent health‐promoting effects. It possesses anti‐obesity, antimicrobial …

Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and …

E Hemmer, P Acosta-Mora, J Mendez-Ramos… - Journal of Materials …, 2017 - pubs.rsc.org
Lanthanide (Ln3+)-based nanoparticles (NPs) with light emission in the ultraviolet (UV),
visible, and near-infrared (NIR) region under NIR excitation are emerging multifunctional …