In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …

The response to DNA damage is critical for cellular homeostasis, tumor suppression,
immunity, and gametogenesis. In order to provide an unbiased and global view of the DNA …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

The 2.5 Å crystal structure of a TATA-box complex with yeast TBP shows that the eight base
pairs of the TATA box bind to the concave surface of TBP by bending towards the major …

Address reprint requests to: Miguel Beato, MD, Institut fur Molekularbiologie und
Tumorforschung, Philipps Universitat, Emil-Mannkopff Strasse 2, 35037 Marburg, Germany …

Activator-dependent transcription in mammalian cells requires upstream stimulatory activity
(USA)-derived cofactors in addition to those present in TFIID. A novel positive cofactor (PC4) …

Using a defined RNA polymerase II (pal II) transcrlptlon system, we have Investigated the
roles of basal factors at discrete stages during the transcription cycle (eg, lnltiatlon, promoter …

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-
binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is …

The structure of an Oct-1 POU domain-octamer DNA complex has been solved at 3.0 Å
resolution. The POU-specific domain contacts the 5′ half of this site (AAAT), and as …