Simple Summary The increasing production of plastics and the failure to properly manage
their post use represent the primary sources of environmental and human contamination …

Simple Summary The incidence of colorectal cancer has increasing dramatically in those
under 50 years of age. These cancers are prominently in the sigmoid colon and rectum. This …

Introduction Standard treatment for patients with locally advanced rectal cancer (LARC)
includes neoadjuvant chemoradiotherapy (nCRT) with fluoropyrimidines, followed by …

Background The molecular profile of early-onset colonic cancer is undefined. This study
evaluated clinicopathological features and oncological outcomes of young patients with …

Simple Summary Colorectal cancer is becoming more common in adults under 50. This
trend has been observed worldwide, the reasons for which are unclear. Research has …

Importance Neoadjuvant chemoradiotherapy (CRT) is the standard of care for advanced
rectal cancer. Yet, estimating response to CRT remains an unmet clinical challenge …

Background Colon cancer in young patients is often associated with hereditary syndromes;
however, in early-onset rectal cancer, mutations of these genes are rarely observed. The …

It is estimated that worldwide nearly 2 million patients were diagnosed with colorectal cancer
in 2020, with nearly a million deaths from the disease in the same interval 1. The incidence …

Purpose//objectives A disproportionate incidence's increase of rectal cancer in patients
younger than 50 years of age. The ESMO and NCCN recommendations are not age-specific …

Microsatellite instability is rare in rectal cancer and associated with younger age of onset
and Lynch syndrome. All rectal cancers should be tested for microsatellite instability prior to …