The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

The diversity of potential applications for protein‐engineered materials has undergone
profound recent expansion through a rapid increase in the library of domains that have been …

Simple Summary TRAIL is a death ligand cytokine, predominantly used by effector immune
cells to kill malignantly transformed cells. Since its discovery, TRAIL has attracted a lot of …

Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive adult cancers
with an unacceptable prognosis. For this reason novel therapies accounting for PDAC …

The resistance of glioma cells to a number of antitumor agents and the highly invasive
nature of glioma cells that escape the primary tumor mass are key impediments to the …

Many therapeutic proteins and protein subunit vaccines contain heterologous trimerization
domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 …

Glioblastoma (GBM) is a lethal primary malignant brain tumor with no current effective
treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have …

Ligands of the tumor necrosis factor superfamily (TNFSF) interact with members of the TNF
receptor superfamily (TNFRSF). TNFSF ligand-TNFRSF receptor interactions have been …

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong
to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics …