Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

INTRODUCTION Understanding the genetic differences that make us human is a long-
standing endeavor that requires the comprehensive discovery and comparison of all forms …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs).
Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain …

Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …

Transcription factors play vital roles in neuron development; however, little is known about
the role of these proteins in maintaining neuronal homeostasis. Here, we show that the …

Gangliosides are sialic acid‐containing glycosphingolipids. They occur especially on the
cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in …

Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues.
They are essential compounds at the outer leaflet of the plasma membrane, where they …