Receptor tyrosine kinase targeting in glioblastoma: performance, limitations and future approaches

O Alexandru, C Horescu, AS Sevastre, C Cioc… - Contemporary …, 2020 - termedia.pl
From all central nervous system tumors, gliomas are the most common. Nowadays,
researchers are looking for more efficient treatments for these tumors, as well as ways for …

Antidepressants with anti‐tumor potential in treating glioblastoma: A narrative review

B Abadi, Y Shahsavani, M Faramarzpour… - Fundamental & …, 2022 - Wiley Online Library
Glioblastoma multiforme (GBM) is known as the deadliest form of brain tumor. In addition, its
high treatment resistance, heterogeneity, and invasiveness make it one of the most …

A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo

SS Kuduvalli, PS Daisy, A Vaithy… - Frontiers in …, 2023 - frontiersin.org
Glioma is the most devastating high-grade tumor of the central nervous system, with dismal
prognosis. Existing treatment modality does not provide substantial benefit to patients and …

Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach

M Mendes, J Basso, J Silva, T Cova, J Sousa… - International Journal of …, 2020 - Elsevier
Ultra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and
biodegradable colloidal systems, claiming a broad set of advanced features suitable for …

Viral vectors as gene therapy agents for treatment of glioblastoma

O Mozhei, A G. Teschemacher, S Kasparov - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma is the most malignant cancer of the brain and current
therapeutic strategies are clearly inadequate. In addition to surgical intervention …

Six Decades of Dopamine Hypothesis: Is Aryl Hydrocarbon Receptor the New D2?

A Sfera - Reports, 2023 - mdpi.com
In 1957, Arvid Carlsson discovered that dopamine, at the time believed to be nothing more
than a norepinephrine precursor, was a brain neurotransmitter in and of itself. By 1963 …

Potassium ion channels in glioma: From basic knowledge into therapeutic applications

S Younes, N Mourad, M Salla, M Rahal… - Membranes, 2023 - mdpi.com
Ion channels, specifically those controlling the flux of potassium across cell membranes,
have recently been shown to exhibit an important role in the pathophysiology of glioma, the …

Novel therapeutics and drug-delivery approaches in the modulation of glioblastoma stem cell resistance

SB Smiley, H Zarrinmayeh, SK Das, KE Pollok… - Therapeutic …, 2022 - Taylor & Francis
Glioblastoma (GBM) is a deadly malignancy with a poor prognosis. An important factor
contributing to GBM recurrence is high resistance of GBM cancer stem cells (GSCs). While …

Hemoglobin levels and red blood cells distribution width highlights glioblastoma patients subgroup with improved median overall survival

T Kaisman-Elbaz, Y Elbaz, V Merkin, L Dym… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma multiforme (GBM) is known for its dismal prognosis, though its dependence on
patients' readily available RBCs parameters is not fully established. In this work, 170 GBM …

Glioblastoma cusa fluid protein profiling: A comparative investigation of the core and peripheral tumor zones

G La Rocca, GA Simboli, F Vincenzoni, DV Rossetti… - Cancers, 2020 - mdpi.com
Simple Summary The biological processes responsible for the high infiltration and
recurrence rate of glioblastoma multiforme, the most frequent and aggressive primary brain …