Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Ferroptosis is a new form of programmed cell death characterized by the accumulation of
iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that …

The initiation and execution of cell death can be regulated by various lipids. How the levels
of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Simple Summary The dysregulation of ACSL3 and ACSL4, which belong to the long-chain
fatty acyl CoA synthetase family (ACSLs), affects the behavior of various cancer cells. This …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of
polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 …

Ferroptosis, a recently identified form of non-apoptotic cell death, is involved in several
physiological and pathological processes. Although lipid peroxidation plays a central role in …

Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in
morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …