Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic
processes. Adenosine is an ancient extracellular signalling molecule that can regulate …

Receptors for extracellular nucleotides are widely expressed by mammalian cells. They
mediate a large array of responses ranging from growth stimulation to apoptosis, from …

BACKGROUND AND PURPOSE Cannabinoid receptor activation induces prostate
carcinoma cell (PCC) apoptosis, but cannabinoids other than Δ9‐tetrahydrocannabinol …

Tumor cells overcome anti‐tumor responses in part through immunosuppressive
mechanisms. There are several immune modulatory mechanisms. Among them, adenosine …

Background: To investigate the effects of curcumin on miR-34a and proliferation of gastric
cancer cells. Materials and Methods: Human gastric cancer cell line SGC-7901 was divided …

Adenosine is a regulatory molecule with widespread physiological effects in almost every
cells and acts as a potent regulator of cell growth. Adenosine has been shown to inhibit cell …

Background CD73 has both enzymatic and non-enzymatic functions in cells. As a
nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into …

The role of the A 2B adenosine receptor (AR) in prostate cell death and growth was studied.
The A 2B AR gene expression quantified by real-time quantitative RT-PCR and Western blot …

It is well nown that the metabolic factors play an important role in the regulation of
angiogenesis. Increased metabolic activity leads to decreased oxygen levels and causes …