Antibody–drug conjugates (ADCs) harness the highly specific targeting capabilities of an
antibody to deliver a cytotoxic payload to specific cell types. They have garnered …

The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Interactions among biomacromolecules, predominantly noncovalent, underpin biological
processes. However, recent advancements in biospecific chemistry have enabled the …

The site-directed chemical conjugation of antibodies remains an area of great interest and
active efforts within the antibody–drug conjugate (ADC) community. We previously reported …

Site-selective protein modification is of significant interest in chemical biology research, with
lysine residues representing a particularly challenging target. Whilst lysines are popular for …

Many fields in chemical biology and synthetic biology require effective bioconjugation
methods to achieve their desired functions and activities. Among such biomolecule …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

While electrophilic reagents for histidine labeling have been developed, we report an
umpolung strategy for histidine functionalization. A nucleophilic small molecule, 1-methyl-4 …

Site-selective acetylation of a single lysine residue in a protein that reaches a lysine
acetyltransferase's accuracy, precision, and reliability is challenging. Here, we report a …

Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as
compared to small cytotoxic molecules alone and have shown the evidence to overcome …