Today, persistent and uncontrolled inflammation is appreciated to play a pivotal role in many
diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic …

The resolution of inflammation has emerged as a critical endogenous process that protects
host tissues from prolonged or excessive inflammation that can become chronic. Failure of …

Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive
events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular …

Non-resolving lung inflammation and Pseudomonas aeruginosa infections are the
underlying cause of morbidity and mortality in cystic fibrosis (CF). The endogenous lipid …

Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation.
An altered neutrophil phenotype may contribute to inadequate resolution, which is known to …

An excessive, non‐resolving inflammatory response underlies severe COVID‐19 that may
have fatal outcomes. Therefore, the investigation of endogenous pathways leading to …

Targeting hypoxia-sensitive pathways in immune cells is of interest in treating diseases.
Here, we demonstrate that physiologic hypoxia (1% O2), as encountered in bone marrow …

Angiogenesis, the growth of new blood vessels, plays a critical role in tissue repair and
regeneration, as well as in cancer. A paradigm shift is emerging in our understanding of the …

Sickle cell disease (SCD) is a monogenic red blood cell (RBC) disorder with high morbidity
and mortality. Here, we report, for the first time, the impact of SCD on the bone marrow (BM) …