BACKGROUND Endometrium is a vital multicellular tissue for progression of pregnancy.
Forkhead box O1 (FoxO1) transcription factor plays an important role in the endometrium as …

Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

Keratoconus is characterised by reduced rigidity of the cornea with distortion and focal
thinning that causes blurred vision, however, the pathogenetic mechanisms are unknown. It …

In the past few years we have seen a great acceleration of discoveries in the field of
keratoconus including new treatments, diagnostic tools, genomic and molecular …

Keratoconus, a progressive corneal ectasia, is a complex disease with both genetic and
environmental risk factors. The exact etiology is not known and is likely variable between …

Importance Keratoconus is an important cause of visual loss in young adults, but little is
known about its genetic causes. Understanding the genetic determinants of corneal …

Purpose Keratoconus (KC) is the most common primary ectatic corneal disease,
characterized by progressive thinning of the cornea, affecting its shape and structure and …

Objective We previously reported that mutations in inner mitochondrial membrane peptidase
2-like (Immp2l) increase infarct volume, enhance superoxide production, and suppress …

Background/aims SLC4A11 is the only known causative gene of congenital hereditary
endothelial dystrophy (CHED). Mutation screenings have shown that most but not all …

Background Keratoconus (KC) is a prevalent corneal condition with a modest genetic basis.
Recent studies have reported significant genetic associations in multi-ethnic cohorts …