Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Despite their concomitant emergence in the 1990s, γ‐peptide foldamers have not developed
as fast as β‐peptide foldamers and to date, only a few γ‐oligomer structures have been …

We report the first NMR and X‐ray diffraction (XRD) structures of an unusual 13/11‐helix
(alternating i, i+ 1 {NH− O= C} and i, i+ 3 {C= O− H− N} H‐bonds) formed by a heteromeric 1 …

Double helices are not common in polypeptides and proteins except in the peptide antibiotic
gramicidin A and analogous l, d‐peptides. In contrast to natural polypeptides, remarkable β …

The α, β‐unsaturated γ‐lactams have been found in many biologically active peptide natural
products. Due to their biological activities, extensive efforts have been made in the literature …

Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer
mimics with new and improved properties in a physiological environment, and in turn could …

The recent approval of antibody-based therapy for targeting the clearance of amyloid
plaques fuels the research in designing small molecules and peptide inhibitors to target the …

A bio-inspired, photocatalytic E→ Z isomerization of cinnamides is reported using
inexpensive (−)-riboflavin (vitamin B 2) under irradiation at λ= 402 nm. This operationally …

Peptides that are composed of an alternating pattern of α-and γ-amino acids are potentially
valuable as metabolism-resistant bioactive agents. For optimal function, some kind of …

Enantiodiscriminative helix formation was observed for β-peptide H14 helices. This
observation is caused by the synperiplanar orientation of H–O atoms which is more …