Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a
homologous DNA sequence (ie, homologous recombination [HR]), focusing mainly on yeast …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …

Background: The response of eukaryotic cells to double-strand breaks in genomic DNA
includes the sequestration of many factors into nuclear foci. Recently it has been reported …

The underlying mechanism behind age-induced wastage of the human ovarian follicle
reserve is unknown. We identify impaired ATM (ataxia-telangiectasia mutated)–mediated …

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …