The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Monoamine oxidase inhibitors were among the first antidepressants to be discovered and
have long been used as such. It now seems that many of these agents might have …

Among the most widely used models of Parkinson's disease (PD) are those that employ
toxins, especially 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Depending on the …

Interactions of Nitrogen-Containing Xenobiotics with Monoamine Oxidase (MAO) Isozymes A
and B: SAR Studies on MAO Substrates and Inhibitors | Chemical Research in Toxicology …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

A great deal has been learned about the behaviour of monoamine oxidase in the 75 years
since it was first discovered, but there is still a great deal left to understand. This review …

Monoamine oxidase (MAO) is responsible for the oxidation of biogenic and dietary amines. It
exists as two isoforms, A and B, which have a 70% amino acid identity and different …

Caffeine and more specific antagonists of the adenosine A 2A receptor recently have been
found to be neuroprotective in the MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) …

The aim of the present work was to characterize the molecular basis of oxidative-induced
death, a process that has been implicated in eye diseases like glaucoma, in RGC-5 cells, an …

Pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and
Huntington's disease (HD) are closely related to the formation of protein aggregates and …