[HTML][HTML] Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease
Alzheimer's disease (AD) remains a significant healthcare challenge, necessitating
innovative therapeutic approaches to address its complex and multifactorial nature …
innovative therapeutic approaches to address its complex and multifactorial nature …
Design, synthesis, molecular docking and DFT studies on novel melatonin and isatin based azole derivatives
In order to address the pressing demand for newer broad-spectrum antifungal medicines
with enhanced activity, computer modelling was utilised to rationally develop newer …
with enhanced activity, computer modelling was utilised to rationally develop newer …
A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease
YP Singh, H Kumar - Chemical Biology & Drug Design, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a common age‐related neurodegenerative brain disorder
characterized by the impairment in memory and other cognitive functions. Although there is …
characterized by the impairment in memory and other cognitive functions. Although there is …
Selective butyrylcholinesterase inhibition by isatin dimers and 3-indolyl-3-hydroxy-2-oxindole dimers
KM Reiland, TJ Eckroat - Bioorganic & Medicinal Chemistry Letters, 2022 - Elsevier
Polymethylene-linked isatin dimers 1a-g and 3-indolyl-3-hydroxy-2-oxindole dimers 2a-g
were synthesized and are reported here as selective butyrylcholinesterase (BChE) …
were synthesized and are reported here as selective butyrylcholinesterase (BChE) …
Evaluation of N-alkyl isatins and indoles as acetylcholinesterase and butyrylcholinesterase inhibitors
KN Alcorn, IA Oberhauser, MD Politeski… - Journal of Enzyme …, 2024 - Taylor & Francis
Two series of N-alkyl isatins and N-alkyl indoles varying in size of the alkyl group were
synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and …
synthesised and evaluated for inhibition of acetylcholinesterase (AChE) and …
[PDF][PDF] Design and synthetic approach of novel hybrid molecules for treatment of Alzheimer's disease
A Dimkovski, E Mihajloska, O Gigopulu, Z Naumovska… - academia.edu
Alzheimer's disease (AD) is an irreversible, progressive, neurodegenerative disorder and
the foremost cause of senile dementia worldwide. Even though the particular molecular …
the foremost cause of senile dementia worldwide. Even though the particular molecular …