Echinocandins–structure, mechanism of action and use in antifungal therapy

M Szymański, S Chmielewska… - Journal of enzyme …, 2022 - Taylor & Francis
With increasing number of immunocompromised patients as well as drug resistance in fungi,
the risk of fatal fungal infections in humans increases as well. The action of echinocandins is …

Antifungal resistance and the role of new therapeutic agents

A Logan, A Wolfe, JC Williamson - Current Infectious Disease Reports, 2022 - Springer
Abstract Purpose of Review Advances in health care over time have led to an evolution in
the epidemiology of invasive fungal infections. There is an increasing concern for antifungal …

Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts

G Spengler, M Gajdács, MG Donadu, M Usai… - Microorganisms, 2022 - mdpi.com
As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and
a disparity in the commercialization of novel antimicrobial agents, scientists have been …

Comparison of In Vitro Killing Activity of Rezafungin, Anidulafungin, Caspofungin, and Micafungin against Four Candida auris Clades in RPMI-1640 in the Absence …

R Kovács, Z Tóth, JB Locke, L Forgács, G Kardos… - Microorganisms, 2021 - mdpi.com
Candida auris is an emerging and frequently multidrug-resistant pathogen against which the
echinocandins are the preferred therapeutic option. We compared killing activities of …

Invasive Candida infection: epidemiology, clinical and therapeutic aspects of an evolving disease and the role of rezafungin

A Oliva, FG De Rosa, M Mikulska, F Pea… - Expert Review of Anti …, 2023 - Taylor & Francis
ABSTRACT Introduction Invasive Candida Infections (ICIs) have undergone a series of
significant epidemiological, pathophysiological, and clinical changes during the last …

Heightened Efficacy of Anidulafungin When Used in Combination with Manogepix or 5-Flucytosine against Candida auris In Vitro

LLH John, DD Thomson, T Bicanic… - Antimicrobial agents …, 2023 - Am Soc Microbiol
Candida auris is an emerging, multidrug-resistant fungal pathogen that causes refractory
colonization and life-threatening, invasive nosocomial infections. The high proportion of C …

Recent advances and future perspectives in the pharmacological treatment of Candida auris infections

DR Giacobbe, L Magnasco, C Sepulcri… - Expert Review of …, 2021 - Taylor & Francis
Introduction Candida auris is responsible for hospital outbreaks worldwide. Some C. auris
isolates may show concomitant resistance to azoles, echinocandins, and polyenes, thereby …

[HTML][HTML] Small molecules for combating multidrug-resistant superbug Candida auris infections

J Tu, N Liu, Y Huang, W Yang, C Sheng - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Candida auris is emerging as a major global threat to human health. C. auris infections are
associated with high mortality due to intrinsic multi-drug resistance. Currently, therapeutic …

Candida auris: Epidemiology and Antifungal Strategy

EF Eix, JE Nett - Annual Review of Medicine, 2024 - annualreviews.org
Candida auris is a recently emerged fungal pathogen that causes severe infections in
healthcare settings around the globe. A feature that distinguishes C. auris from other fungal …

Synergistic Interaction of Caspofungin Combined with Posaconazole against FKS Wild-Type and Mutant Candida auris Planktonic Cells and Biofilms

N Balla, F Kovács, B Balázs, AM Borman, A Bozó… - Antibiotics, 2022 - mdpi.com
Candida auris is a potential multidrug-resistant pathogen able to cause biofilm-associated
outbreaks, where frequently indwelling devices are the source of infections. The number of …