Cancer neoepitopes viewed through negative selection and peripheral tolerance: a new path to cancer vaccines
PK Srivastava - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
A proportion of somatic mutations in tumors create neoepitopes that can prime T cell
responses that target the MHC I–neoepitope complexes on tumor cells, mediating tumor …
responses that target the MHC I–neoepitope complexes on tumor cells, mediating tumor …
CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading
Y Sun, RA Pumroy, L Mallik, A Chaudhuri… - Proceedings of the …, 2025 - pnas.org
Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive
immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and …
immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and …