Sifting through the Noise: A Survey of Diffusion Probabilistic Models and Their Applications to Biomolecules

T Norton, D Bhattacharya - Journal of Molecular Biology, 2024 - Elsevier
Diffusion probabilistic models have made their way into a number of high-profile
applications since their inception. In particular, there has been a wave of research into using …

A large-scale foundation model for rna function and structure prediction

S Zou, T Tao, S Mahbub, CN Ellington, RJ Algayres… - bioRxiv, 2024 - biorxiv.org
Originally marginalized as an intermediate in the information flow from DNA to protein, RNA
has become the star of modern biology, holding the key to precision therapeutics, genetic …

RNACG: A Universal RNA Sequence Conditional Generation model based on Flow-Matching

L Gao, ZJ Lu - arXiv preprint arXiv:2407.19838, 2024 - arxiv.org
RNA plays a crucial role in diverse life processes. In contrast to the rapid advancement of
protein design methods, the work related to RNA is more demanding. Most current RNA …

[PDF][PDF] Secondary-Structure-Informed RNA Inverse Design via Relational Graph Neural Networks

A Manzourolajdad, M Mohebbi - 2024 - preprints.org
RNA inverse design is an essential part of many RNA therapeutics strategies. To date, there
have been great advances in the computationally-driven RNA design. Current machine …

GeoRDe: Tertiary Structure-based RNA Design With Multiple Geometric Constraint

X Guo, X Zeng, Y Qi, Y Cheng - openreview.net
Functional RNA sequence design plays an essential role in the regulation of life processes.
The RNA inverse folding problem, which involves designing nucleic acid sequences based …