Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products

B Tembeni, OE Idowu, R Benrkia, S Boutahiri… - Natural Products and …, 2024 - Springer
Biotransformation is a process in which molecules are modified in the presence of a
biocatalyst or enzymes, as well as the metabolic alterations that occur in organisms from …

Progress on metabolites of Astragalus medicinal plants and a new factor affecting their formation: Biotransformation of endophytic fungi

DH Feng, JL Cui - Archiv der Pharmazie, 2024 - Wiley Online Library
It is generally believed that the main influencing factors of plant metabolism are genetic and
environmental factors. However, the transformation and catalysis of metabolic intermediates …

The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity

S Yilmaz, E Bedir, PB Kirmizibayrak - Free Radical Biology and Medicine, 2022 - Elsevier
Aging is well-characterized by the gradual decline of cellular functionality. As redox balance,
proteostasis, and telomerase systems have been found to be associated with aging and age …

Neuroprotective metabolites via fungal biotransformation of a novel sapogenin, cyclocephagenol

M Küçüksolak, G Üner, P Ballar Kırmızıbayrak… - Scientific Reports, 2022 - nature.com
Abstract Cyclocephagenol (1), a novel cycloartane-type sapogenin with tetrahydropyran
unit, is only encountered in Astragalus species. This rare sapogenin has never been a topic …

Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives

C Chen, K Song, Y Zhang, C Chu, B Fan, Y Song… - Phytochemistry, 2021 - Elsevier
Biotransformation of betulinic acid was carried out with Circinella muscae CGMCC 3.2695
and Cunninghamella echinulata CGMCC 3.970, yielded six previously undescribed …

Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1

G Ekiz, S Duman, E Bedir - Phytochemistry, 2018 - Elsevier
The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated
sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus …

Microbial Transformation of Cycloastragenol and Astragenol by Endophytic Fungi Isolated from Astragalus Species

G Ekiz, S Yılmaz, H Yusufoglu… - Journal of natural …, 2019 - ACS Publications
Biotransformation of Astragalus sapogenins (cycloastragenol (1) and astragenol (2)) by
Astragalus species originated endophytic fungi resulted in the production of five new …

Anti-inflammatory 18β-glycyrrhetinin acid derivatives produced by biocatalysis

B Fan, B Jiang, S Yan, B Xu, H Huang, G Chen - Planta medica, 2019 - thieme-connect.com
In this study, the biocatalysis of 18β-glycyrrhetinic acid by two strains of filamentous fungi,
namely Rhizopus arrhizus AS 3.2893 and Circinella muscae AS 3.2695, was investigated …

Biotransformation of betulin by Mucor subtilissimus to discover anti-inflammatory derivatives

J Li, B Jiang, C Chen, B Fan, H Huang, G Chen - Phytochemistry, 2019 - Elsevier
Biotransformation of lupane-type triterpenoid betulin was carried out with Mucor
subtilissimus CGMCC 3.2456. Yielded nine previously undescribed hydroxylated …

Biotransformation of Betulonic Acid by the Fungus Rhizopus arrhizus CGMCC 3.868 and Antineuroinflammatory Activity of the Biotransformation Products

KN Song, YJ Lu, CJ Chu, YN Wu… - Journal of Natural …, 2021 - ACS Publications
Biotransformation of betulonic acid (1) by Rhizopus arrhizus CGMCC 3.868 resulted in the
production of 16 new (3, 5, 6, and 9–21) and five known compounds. Structures of the new …