Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …

Background: The aim of this review was to identify the mechanisms by which serotonin
receptors involved at the central level are able to modulate the nociceptive response. Pain is …

Beyond direct synaptic communication, neurons are able to talk to each other without
making synapses. They are able to send chemical messages by means of diffusion to target …

The ligand-gated ion channel superfamily of neurotransmitter receptors are proteins
responsible for rapid transmission of nerve impulses at the synapse and have, therefore …

The modulation of ionotropic γ-aminobutyric acid (GABA) receptors (GABA-gated Cl−
channels) by a group of natural and synthetic flavonoids was studied in electrophysiological …

Following the cloning and sequencing of the A subunit of the 5‐HT3 receptor, two
alternatively spliced isoforms, 5‐HT3‐AS and 5‐HT3‐AL, have been identified. In order to …