A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility

RJ Jirsaraie, AJ Gorelik, MM Gatavins, DA Engemann… - Patterns, 2023 - cell.com
Brain aging is a complex, multifaceted process that can be challenging to model in ways that
are accurate and clinically useful. One of the most common approaches has been to apply …

Explaining variation in individual aging, its sources, and consequences: A comprehensive conceptual model of human aging

K Rothermund, C Englert, D Gerstorf - Gerontology, 2023 - karger.com
We define aging as a characteristic deterioration in one (or more) observable attributes of an
organism that typically occurs during later life. With this narrow functional definition, we gain …

Toward MR protocol-agnostic, unbiased brain age predicted from clinical-grade MRIs

PA Valdes-Hernandez, C Laffitte Nodarse… - Scientific Reports, 2023 - nature.com
The difference between the estimated brain age and the chronological age ('brain-PAD')
could become a clinical biomarker. However, most brain age models were developed for …

[HTML][HTML] Brain health in diverse settings: How age, demographics and cognition shape brain function

H Hernandez, S Baez, V Medel, S Moguilner… - NeuroImage, 2024 - Elsevier
Diversity in brain health is influenced by individual differences in demographics and
cognition. However, most studies on brain health and diseases have typically controlled for …

[HTML][HTML] Brain age prediction via cross-stratified ensemble learning

X Li, Z Hao, D Li, Q Jin, Z Tang, X Yao, T Wu - NeuroImage, 2024 - Elsevier
As an important biomarker of neural aging, the brain age reflects the integrity and health of
the human brain. Accurate prediction of brain age could help to understand the underlying …

Quantifying Brain and Cognitive Maintenance as Key Indicators for Sustainable Cognitive Aging: Insights from the UK Biobank

L Lin, M Xiong, Y Jin, W Kang, S Wu, S Sun, Z Fu - Sustainability, 2023 - mdpi.com
Age-related cognitive decline is a global phenomenon that affects individuals worldwide.
The course and extent of this decline are influenced by numerous factors, such as genetics …

[HTML][HTML] Feasibility of brain age predictions from clinical T1-weighted MRIs

PA Valdes-Hernandez, CL Nodarse, JH Cole… - Brain Research …, 2023 - Elsevier
An individual's brain predicted age minus chronological age (brain-PAD) obtained from
MRIs could become a biomarker of disease in research studies. However, brain age reports …

[HTML][HTML] Machine Learning and Deep Learning Approaches in Lifespan Brain Age Prediction: A Comprehensive Review

Y Wu, H Gao, C Zhang, X Ma, X Zhu, S Wu, L Lin - Tomography, 2024 - mdpi.com
The concept of 'brain age', derived from neuroimaging data, serves as a crucial biomarker
reflecting cognitive vitality and neurodegenerative trajectories. In the past decade, machine …

Brain Age Estimation with a Greedy Dual-Stream Model for Limited Datasets

I Kianian, H Sajedi - Neurocomputing, 2024 - Elsevier
Brain age estimation involves predicting an individual's biological age from their brain
images. This process offers valuable insights into the aging process and the progression of …

A review of artificial intelligence-based brain age estimation and its applications for related diseases

M Azzam, Z Xu, R Liu, L Li, K Meng Soh… - Briefings in …, 2024 - academic.oup.com
The study of brain age has emerged over the past decade, aiming to estimate a person's
age based on brain imaging scans. Ideally, predicted brain age should match chronological …