R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

Aberrant R-loop structures are increasingly being realized as an important contributor to
human disease. R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids …

Tudor domain-containing protein 3 (TDRD3) is a major methylarginine effector molecule that
reads methyl-histone marks and facilitates gene transcription. However, the underlying …

R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the
RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R …

THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents
transcription‐associated recombination. Whether or not it has a ubiquitous role in the …

R-loops, three-stranded structures that form when transcripts hybridize to chromosomal
DNA, are potent agents of genome instability. This instability has been explained by the …

Genomes undergo different types of sporadic alterations, including DNA damage, point
mutations, and genome rearrangements, that constitute the basis for evolution. However …

Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …