Heart disease and stroke statistics—2023 update: a report from the American Heart Association
CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Prevention of cardiorenal damage: importance of albuminuria
LM Ruilope, A Ortiz, A Lucia, B Miranda… - European Heart …, 2023 - academic.oup.com
Chronic kidney disease (CKD) is projected to become a leading global cause of death by
2040, and its early detection is critical for effective and timely management. The current …
2040, and its early detection is critical for effective and timely management. The current …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
P Schlosser, N Scherer, F Grundner-Culemann… - Nature …, 2023 - nature.com
The kidneys operate at the interface of plasma and urine by clearing molecular waste
products while retaining valuable solutes. Genetic studies of paired plasma and urine …
products while retaining valuable solutes. Genetic studies of paired plasma and urine …
DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
Comprehensive genetic study of the insulin resistance marker TG: HDL-C in the UK Biobank
Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …
Causal effects of specific gut microbiota on chronic kidney diseases and renal function—A two-sample Mendelian randomization study
Background: Targeting the gut microbiota may become a new therapeutic to prevent and
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship …
Insights from complex trait fine-mapping across diverse populations
Despite the great success of genome-wide association studies (GWAS) in identifying genetic
loci significantly associated with diseases, the vast majority of causal variants underlying …
loci significantly associated with diseases, the vast majority of causal variants underlying …
Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses
Background: End-stage renal disease is associated with a high risk of cardiovascular
events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally …
events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally …